Nmr diffusion coefficient study of steroid cyclodextrin inclusion complexes

The result is a shift in the temperature of maximum density to lower temperatures. At high enough pressures the density maximum is shifted to below 0 °C (at just over MPa). Above MPa it cannot be observed above the melting point (now at K), except in supercooled water [ 1860 ], and it cannot be observed at all above about 200 MPa where it encounters the homogeneous nucleation limit. The stronger and more linear hydrogen bonding in D 2 O gives rise to a 25% smaller shift in the temperature of maximum density (from °C at MPa) with respect to increasing pressure [ 726 ].

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[3] K. T. Gillen, D. C. Douglass, M. J. R. Hoch, Self-Diffusion in Liquid Water to -31°C, The Journal of Chemical Physics, Vol. 57, No. 12, 5117-5119 (1972)
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Solvent suppression is needed when the solvent contains non-deuterated proton atoms, because the solvent signal could be over 1000 times stronger comparing to other signals of interest. It is a common technique for protein NMR since protein samples usually dissolve in 90%H2O/10%D2O solution instead of 100% D2O in order to investigate exchangble protons such as amide groups. In this case water suppression is absolutely necessary. On the other hand, the introduction of cold probes brings 3-4 times sensitivity gain over room temperature probes. Although it is great for some precious dilute samples, solvent suppression becomes more difficult with cold probes.

Nmr diffusion coefficient study of steroid cyclodextrin inclusion complexes

nmr diffusion coefficient study of steroid cyclodextrin inclusion complexes

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