Some side effects of prohormone supplementation can include acne breakouts, temporary hair loss, and increased sensitivity of the breast tissue. To help minimize these undesirable side effects, many users add a process known as post cycle therapy. Completing post cycle therapy entails taking an additional supplement that will offset spikes in testosterone levels and clear any toxins that have accumulated in the liver. Since prohormones are processed and broken down in the liver, it can add more stress on this organ than normal. These supplements can also lead to increases in blood pressure, which is another reason why post cycle therapy is a good idea.
Health problems. Lots of things that can go wrong here but I wont bother to go into too much detail because you have heard it all before. These problems are very dosage dependent and drug dependent. Enlargement of the heart is probably the biggest problem. Although enlarging your heart sounds like a good thing, its very, very bad and is what leads to heart attacks in young bodybuilders. Damaging your kidneys and liver is another relatively common problem as the body works overtime to filter out stuff that it doesnt want. Then there is the problem with natural testosterone production being shut down.
Franklin D. Roosevelt promised in the 1932 presidential election to end the prohibition for alcohol and fulfilled that promise in 1933. However, Roosevelt supported more restrictive laws from 1935 for cannabis.  The Treasury Department created a new department in 1930 named the Federal Bureau of Narcotics. Harry J. Anslinger – who previously held the position of Assistant Prohibition Commissioner – became the Commissioner of Narcotics in 1930. Commissioner Anslinger's report in 1935 noted: "In the absence of Federal legislation on the subject, the States and cities should rightfully assume the responsibility for providing vigorous measures for the extinction of this lethal weed, and it is therefore hoped that all public-spirited citizens will earnestly enlist in the movement urged by the Treasury Department to adjure intensified enforcement of marijuana laws."  By 1937, 46 out of 48 states had officially classified cannabis as a narcotic along the lines of morphine, heroin, and cocaine. Anslinger's campaign supported the passing of the Marihuana Tax Act of 1937 .