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A prospective multicenter, open-label trial evaluated the pharmacokinetic profile, tolerability, safety and efficacy of high-dose KALETRA with or without concurrent NNRTI therapy (Group 1: 400/100 mg/m 2 twice daily + ≥ 2 NRTIs; Group 2: 480/120 mg/m 2 twice daily + ≥ 1 NRTI + 1 NNRTI) in 26 children and adolescents ≥ 2 years to < 18 years of age who had failed prior therapy. Patients also had saquinavir mesylate added to their regimen. This strategy was intended to assess whether higher than approved doses of KALETRA could overcome protease inhibitor cross-resistance. High doses of KALETRA exhibited a safety profile similar to those observed in previous trials; changes in HIV-1 RNA were less than anticipated; three patients had HIV-1 RNA <400 copies/mL at Week 48. CD4+ cell count increases were noted in the eight patients who remained on treatment for 48 weeks [see Adverse Reactions ( ), Clinical Pharmacology ( )] .
It sounds like you’re doing a great job with those babies! Making it to 32 weeks is definitely a milestone! I had my twins (di/di) 12 weeks ago via c-section, at 35 weeks (they were measuring on the smaller side) they ended up weighing and and only spent 5 &6 days in the NICU which my husband and I were not expecting. They told us to expect about a two week stay, so we were pleasantly surprised! The doctors told us that they always tell you they will stay longer in the NICU just to be on the safe side, but normally get discharged earlier. Stay strong momma, these babies will be home in your arms with their sisters before you know it!